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1996-02-27
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Document 0265
DOCN M9630265
TI T cell responses in macaques after vaginal immunization with particulate
SIV p27 antigen.
DT 9603
AU Panagiotidi C; Bergmeier LA; Gearing AJ; Adams SE; Lehner T; Department
of Immunology, UMDS, Guy's Hospital, London, United; Kingdom.
SO Adv Exp Med Biol. 1995;371B:1575-80. Unique Identifier : AIDSLINE
MED/96001797
AB Rhesus monkeys were immunized by the vaginal and oral routes using a
recombinant particulate simian immunodeficiency virus (SIV) antigen.
Augmenting vaginal by oral immunization in macaques elicits
proliferative CD4+ T cells in the circulation which are specific to the
immunizing p27 antigen. Reconstitution of enriched CD4+ T cells, B cells
and macrophages from circulating mononuclear cells help B cells in
specific IgA anti-p27 antibody synthesis. The results suggest that
augmented vaginal immunization induces systemic CD4+ T and B cell
responses which may play a part in the protective immunity against SIV
(HIV) infection.
DE Administration, Intravaginal Administration, Oral Animal Antibodies,
Viral/BIOSYNTHESIS Antigens, Viral/*ADMINISTRATION & DOSAGE
B-Lymphocytes/IMMUNOLOGY CD4-Positive T-Lymphocytes/IMMUNOLOGY
CD8-Positive T-Lymphocytes/IMMUNOLOGY Female Gene Products,
gag/*ADMINISTRATION & DOSAGE/*IMMUNOLOGY Human HIV
Infections/IMMUNOLOGY/PREVENTION & CONTROL/TRANSMISSION Immunity,
Mucosal *Immunization Lymphocyte Transformation Macaca fascicularis
Macaca mulatta SAIDS Vaccines/ADMINISTRATION & DOSAGE SIV/*IMMUNOLOGY
T-Lymphocytes/*IMMUNOLOGY Vagina/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).